Throwing Transcription for a Loop: The Role of Chromatin Insulators in the 3D Nucleus
Throwing Transcription for a Loop: The Role of Chromatin Insulators in the 3D Nucleus – Air date: Wednesday, December 14, 2011, 3:00:00 PM Timedisplayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: Interactions among regulatory sequences such as enhancers, promoters and insulators give rise to a three-dimensional structure of the genetic material in the eukaryotic nucleus. We have used 5C and HiC to determine the nature of inter- and intra-chromosomal interactions in the Drosophila genome. The results suggest that each chromosome arm is an independent physical unit in terms of its interactions with the rest of the genome. Each chromosome folds into modules with a hierarchical organization. These modules comprise 80% of the genome, they are composed of different types of chromatin, they have a low gene density, and the genes are expressed at low levels, independent of their chromatin composition. Chromosome modules are separated by inter-module regions that comprise 20% of the genome. Inter-module regions have high gene density and comprise different chromatin types, but genes are expressed at higher levels than in chromosome modules. Inter-chromosome modules contain insulator proteins, which, together with RNA polymerase II, mediate interactions with other inter-chromosome modules. Chromosome modules also interact with each other but these interactions are not enriched in any known proteins. We are attempting to deconstruct this 3D structure into specific classes of interactions and determine their role in gene …
Meth maker sent to slammer
Filed under: willard drug treatment program
Willard Police Detective Jeremy Draper led an investigation which lasted a little more than two weeks and involved METRICH, a 10-county drug task force. The probe resulted in the Feb. 13 arrests of Collier and his … On June 29, she was ordered to …
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Most-Used Diabetes Drug Works in Different Way Than Previously Thought
Filed under: willard drug treatment program
… MD, PhD, the Willard and Rhoda Ware Professor of Medicine, with the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, found that the diabetes drug metformin works in a different way than …
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Who Was Killed in America's Drug War Last Year? [FEATURE]
Filed under: willard drug treatment program
(Our tally includes several cases where people collapsed and died during or immediately after being arrested; the drug link became apparent only weeks or months later when toxicology reports came back. We could have missed others.) …. Danielle Misha …
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